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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Архив акушерства и гинекологии им. В.Ф. Снегирева</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-8726</issn><issn publication-format="electronic">2687-1386</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">35265</article-id><article-id pub-id-type="doi">10.17816/aog35265</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original study articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="zh"><subject>Original study articles</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Angiogenic growth factors in the pathogenesis of pre-eclampsia</article-title><trans-title-group xml:lang="ru"><trans-title>Ангиогенные факторы роста в патогенезе преэклампсии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Murashko</surname><given-names>A. V</given-names></name><name xml:lang="ru"><surname>Мурашко</surname><given-names>Андрей Владимирович</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф., зав. отделением патологии беременности № 1</p></bio><email>murashkoa@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Faizullin</surname><given-names>A. L</given-names></name><name xml:lang="ru"><surname>Файзуллин</surname><given-names>А. Л</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Murashko</surname><given-names>L. E</given-names></name><name xml:lang="ru"><surname>Мурашко</surname><given-names>Л. Е</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">V.I. Kulakov Center of Obstetrics, Gynecology, and Perinatology</institution></aff><aff><institution xml:lang="ru">ФГБУ «Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-09-15" publication-format="electronic"><day>15</day><month>09</month><year>2015</year></pub-date><volume>2</volume><issue>3</issue><issue-title xml:lang="en">VOL 2, NO3 (2015)</issue-title><issue-title xml:lang="ru">ТОМ 2, №3 (2015)</issue-title><fpage>4</fpage><lpage>7</lpage><history><date date-type="received" iso-8601-date="2020-07-21"><day>21</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ООО "Эко-Вектор"</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://archivog.com/2313-8726/article/view/35265">https://archivog.com/2313-8726/article/view/35265</self-uri><abstract xml:lang="en"><p>The pathogenetic mechanisms of pre-eclampsia are reviewed, modern risk factors are described, and probable consequences for the mother during the postpartum period and for the fetus in postnatal life are discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Представлен обзор патогенетических механизмов развития преэклампсии, описаны современные факторы риска, освещены возможные последствия для матери в послеродовом периоде и плода в дальнейшей постнатальной жизни.</p></trans-abstract><kwd-group xml:lang="en"><kwd>pre-eclampsia</kwd><kwd>angiogenic growth factors</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>преэклампсия</kwd><kwd>ангиогенные факторы роста</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Brown M. et al. The classifi cation and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertension in pregnancy: offi cial journal of the International Society for the Study of Hypertension in Pregnancy. 2001: IX-XIV.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Steegers E.A.P. et al. Pre-eclampsia. Lancet. 2010; 376 (9741): 631-44.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Young B.C., Levine R.J., Karumanchi S.A. Pathogenesis of preeclampsia. Ann. Rev. Pathol. 2010; 5: 173-92.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Granger J.P. et al. Reduced uterine perfusion pressure (RUPP) model for studying cardiovascular-renal dysfunction in response to placental ischemia. Methods Mol. Med. 2006; 122: 383-92.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Makris A. et al. Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1. Kidney Int. 2007; 71 (10): 977-84.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Chaiworapongsa T. et al. Pre-eclampsia part 1: current understanding of its pathophysiology. Nat. Rev. Nephrol. 2014; 10 (8): 466-80.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Naljayan M. V., Karumanchi S.A. New Developments in the Pathogenesis of Preeclampsia. Adv. Chronic Kidney Dis. 2013; 20 (3): 265-270.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Levine R.J. et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N. Engl. J. Med. 2006; 355 (10): 992-1005.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Conti E. et al. Growth factors in preeclampsia: A vascular disease model: A failed vasodilation and angiogenic challenge from pregnancy onwards? Cytokine Growth Factor Rev. 2013; 24 (5): 411-25.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Verlohren S., Stepan H., Dechend R. Angiogenic growth factors in the diagnosis and prediction of pre-eclampsia. Clin. Sci. 2011; 122(2): 43-52.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Lassus P. et al. Vascular endothelial growth factor and angiogenin levels during fetal development and in maternal diabetes. Biol. Neonate. 2003; 84 (4): 287-92.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Kleinrouweler C.E. et al. Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia: A systematic review and meta-analysis. BJOG An Int. J. Obstetr. Gynaecol. 2012; 119 (7): 778-87.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Espinoza J. et al. Identifi cation of patients at risk for early onset and/or severe preeclampsia with the use of uterine artery Doppler velocimetry and placental growth factor. Am. J. Obstet. Gynecol. 2007; 196 (4): 326.e1-326.13.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Levine R.J. et al. Circulating angiogenic factors and the risk of preeclampsia. N. Engl. J. Med. 2004; 350 (7): 672-83.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Maynard S.E. et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction hypertension, and proteinuria in preeclampsia. J. Clin. Invest. 2003; 111 (5): 649-58.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Shibuya M. Vascular endothelial growth factor and its receptor system: Physiological functions in angiogenesis and pathological roles in various diseases. J. Biochem. 2013; 153 (1): 13-9.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Romero R. et al. An imbalance between angiogenic and anti-angiogenic factors precedes fetal death in a subset of patients: results of a longitudinal study. J. Matern. Fetal. Neonatal Med. 2010; 23 (12): 1384-99.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Akolekar R. et al. Maternal plasma soluble fms-like tyrosine kinase-1 and free vascular endothelial growth factor at 11 to 13 weeks of gestation in preeclampsia. Prenat. Diagn. 2010; 30 (3): 191-7.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Foidart J.M. et al. Dysregulation of anti-angiogenic agents (sFlt-1, PLGF, and sEndoglin) in preeclampsia-a step forward but not the defi nitive answer. J. Reprod. Immunol. 2009; 82 (2): 105-10.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Kusanovic J. P., Romero R., Chaiworapongsa T., Erez O. et al. A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identifi cation of patients destined to develop preeclampsia. J. Matern. Fetal Neonatal Med. 2009; 22: 1021-38.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Munaut C. et al. Differential expression of Vegfr-2 and its soluble form in preeclampsia. PLoS One. 2012; 7 (3): e33475.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Powe C.E., Levine R.J., Karumanchi S.A. Preeclampsia, a disease of the maternal endothelium: The role of antiangiogenic factors and implications for later cardiovascular disease. Circulation. 2011; 123(24): 2856-69.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Wada Y. et al. Effects of KRN633, an inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase, on vascular development of placenta and fetus of mid-pregnancy in mice. J. Pharmacol. Sci. 2010; 112 (3): 290-8.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Levine R.J. et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N. Engl. J. Med. 2006; 355 (10): 992-1005.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Venkatesha S. et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat. Med. 2006; 12 (6): 642-9.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Mutter W.P., Karumanchi S.A. Molecular mechanisms of preeclampsia. Microvasc. Res. 2008; 75 (1): 1-8.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Perni U. et al. Angiogenic factors in superimposed preeclampsia: A longitudinal study of women with chronic hypertension during pregnancy. Hypertension. 2012; 59 (3): 740-6.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Lai J. et al. Maternal serum soluble endoglin at 30-33 weeks in the prediction of preeclampsia. Fetal Diagn. Ther. 2013; 33 (3): 149-55.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Gaber K., Hamdy E., Hanafy A. Soluble Endoglin as a new marker for prediction of pre-eclampsia in early pregnancy. Middle East Fertil. Soc. J. 2010; 15 (1): 42-6.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Hermes W., Kesteren F. Van, De Groot C.J.M. Preeclampsia and cardiovascular risk. Minerva Ginecol. 2012; 64 (4): 281-92.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Chen C.W., Jaffe I.Z., Karumanchi S.A. Pre-eclampsia and cardiovascular disease. Cardiovasc. Res. 2014; 101 (4): 579-86.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Jayet P.Y. et al. Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia. Circulation. 2010; 122 (5): 488-94.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Eremina V., Jefferson J.A., Kowalewska J., Hochster H. et al. VEGF inhibition and renal thrombotic microangiopathy. N. Engl. J. Med. 2008; 358 (11): 1129-36.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Spaan J.J. et al. Renal function after preeclampsia: A longitudinal pilot study. Nephron-Clin. Pract. 2012; 120 (3): 156-61.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>McDonald S.D. et al. Kidney Disease After Preeclampsia: A Systematic Review and Meta-analysis. Am. J. Kidney Dis. 2010; 55 (6): 1026-39.</mixed-citation></ref></ref-list></back></article>
