V.F.Snegirev Archives of Obstetrics and GynecologyV.F.Snegirev Archives of Obstetrics and GynecologyАрхив акушерства и гинекологии им. В.Ф. Снегирева2313-87262687-1386Eco-Vector3478010.17816/2313-8726-2020-7-2-67-73ReviewsНаучные обзорыResearch ArticleComplications of preeclampsia: etiology, pathogenesis and treatment. Hellp-syndrome (modern concepts and treatment)Осложнения преэклампсии: этиология, патогенез и лечение. Hellp-синдром (современные представления и лечение)Kaptil’nyyVitaliy A.КаптильныйВиталий Александрович
Russian Federation

Kaptil’nyy

к.м.н.

1mgmu@mail.ruReyshtatDiana Yu.РейштатДиана Юрьевна
Russian Federation
Diana.reyshtat@mail.ruAgeyevMikhail B.АгеевМихаил Борисович
Russian Federation

MD, PhD

к.м.н.

mikhaageev@yandex.ruI.M. Sechenov First Moscow State Medical UniversityФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» (Сеченовский университет) Минздрава России180620207267731806202018062020Copyright ©; 2020, Eco-VectorCopyright ©; 2020, ООО "Эко-Вектор"2020Eco-VectorООО "Эко-Вектор"https://archivog.com/2313-8726/article/view/34780

The review described current views on possible complications, their etiology and course. The HELLP syndrome, its definition, etiology, risk factors for its occurrence, as well as the clinical picture are described in detail. Attention is paid to diagnostic studies of HELLP syndrome, its classification is presented. The treatment, methods of anesthesia, complications and prognosis of the above syndrome are presented.

В обзоре отражены современные представления о возможных осложнениях преэклампсии, их этиологии и течении. Подробно описан HELLP-синдром, дано его определение, этиология, факторы риска возникновения, а также клиническая картина. Уделено внимание диагностическим исследованиям HELLP-синдрома, приведена его классификация. Представлены вниманию лечение, способы обезболивания, осложнения и прогноз вышеназванного синдрома.

preeclampsiacomplications of preeclampsiaHELLP syndromepregnancyпреэклампсияосложнения преэклампсииHELLP-синдромбеременностьWolf J.L. Liver disease in pregnancy. Med. Clin. North Am. 1996; 80:1167-87.Gleeson R., Farrell J., Doyle M., Walshe J.J. HELLP syndrome: a condition of varied presentation. Ir. J. Med. Sci. 1996;165: 265-7.Sibai B.M., Ramadan M.K., Usta I., Salama M., Mercer B.M., Friedman S.A. Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome). Am. J. Obstet. Gynecol. 1993; 169:1000-6.Sibai B.M. The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): much ado about nothing? Am. J. Obstet. Gynecol. 1990; 162: 311-6.Tomsen T.R. HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) presenting as generalized malaise. Am. J. Obstet. Gynecol. 1995; 172: 1876-90.Schroder W., Heyl W. HELLP-syndrome. Difficulties in diagnosis and therapy of a severe form of preeclampsia. Clin. Exp. Obstet. Gynecol. 1993; 20: 88-94.Poldre P.A. Haptoglobin helps diagnose the HELLP syndrome. Am. J. Obstet. Gynecol. 1987; 157: 1267.Magann E.F., Perry K.G. Jr, Meydrech E.F., Harris R.L., Chauhan S.P., Martin J.N. Jr. Postpartum corticosteroids: accelerated recovery from the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP). Am. J. Obstet. Gynecol. 1994; 171: 1154-8.Magann E.F., Chauhan S.P., Naef R.W., Blake P.G., Morrison J.C., Martin J.N. Jr. Standard parameters of preeclampsia: can the clinician depend upon them to reliably identify the patient with the HELLP syndrome? Aust. N. Z. J. Obstet. Gynaecol. 1993; 33: 122-6.Neiger R., Trofatter M.O., Trofatter K.F. Jr. D-dimer test for early detection of HELLP syndrome. South Med. J. 1995; 88: 416-9.Audibert F., Fredman S.A., Frangieh A.Y., Sibai B.M. Clinical utility of strict diagnostic criteria for the HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. Am. J. Obstet. Gynecol. 1996; 175: 460-4.Martin J.N. Jr, Blake P.G., Lowry S.L., Perry K.G. Jr, Files J.C., Morrison J.C. Pregnancy complicated by preeclampsia-eclampsia with the syndrome of hemolysis, elevated liver enzymes, and low platelet count: how rapid is postpartum recovery? Obstet. Gynecol. 1990; 76 (5 pt. 1): 737-41.Martin J.N. Jr, Blake P.G., Perry K.G. Jr, McCaul J.F., Hess L.W., Martin R.W. The natural history of HELLP syndrome: patterns of disease progression and regression. Am. J. Obstet. Gynecol. 1991; 164(6 pt. 1):1500-9.Roberts W.E., Perry K.G. Jr, Woods J.B., Files J.C., Blake P.G., Martin J.N. Jr. The intrapartum platelet count in patients with HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome: is it predictive of later hemorrhagic complications? Am. J. Obstet. Gynecol. 1994; 171: 799-804.Barton J.R., Riely C.A., Adamec T.A., Shanklin D.R., Khoury A.D., Sibai B.M. Hepatic histopathologic condition does not correlate with laboratory abnormalities in HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count). Am. J. Obstet .Gynecol. 1992; 167: 1538-43.Barton J.R., Sibai B.M. Hepatic imaging in HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count). Am. J. Obstet. Gynecol. 1996; 174: 1820-7.Weinstein L. Syndrome of hemolysis, elevated liver enzymes and low platelet count: a severe consequence of hypertension in pregnancy. Am. J. Obstet. Gynecol. 1982; 142: 159-67.Visser W., Wallenburg H.C. Temporising management of severe preeclampsia with and without the HELLP syndrome. Br. J. Obstet. Gynaecol. 1995; 102: 111-7.Sibai B.M., Frangieh A.Y. Management of severe preeclampsia. Curr. Opin. Obstet. Gynecol. 1996; 8:110-3.Sibai B.M., Mercer B.M., Schiff E., Friedman S.A. Aggressive versus expectant management of severe preeclampsia at 28 to 32 weeks’ gestation: a randomized controlled trial. Am. J. Obstet. Gynecol. 1994; 171: 818-22.Magann E.F., Bass D., Chauhan S.P., Sullivan D.L., Martin R.W., Martin J.N. Jr. Antepartum corticosteroids: disease stabilization in patients with the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP). Am. J. Obstet. Gynecol. 1994; 171: 1148-53.Waisman G.D., Mayorga L.M., Camera M.I., Vignolo C.A., Martinotti A. Magnesium plus nifedipine: potentiation of hypotensive effect in preeclampsia? Am. J. Obstet. Gynecol. 1988; 159: 308-9.Magann E.F., Graves G.R., Roberts W.E., Blake P.G., Morrison J.C., Martin J.N. Jr. Corticosteroids for enhanced fetal lung maturation in patients with HELLP syndrome: impact on neonates. Aust. N. Z. J. Obstet. Gynaecol. 1993; 33: 131-5.Martin J.N. Jr, Files J.C., Blake P.G., Norman P.H., Martin R.W., Hess W. et al. Plasma exchange for preeclamspia. I. Postpartum use for persistently severe preeclampsia-eclampsia with HELLP syndrome. Am. J. Obstet. Gynecol. 1990; 162: 126-37.Katz V.L., Watson W.J., Thorp J.M. Jr, Hansen W., Bowes W.A. Jr. Treatment of persistent postpartum HELLP syndrome with plasmapheresis. Am. J. Perinatol. 1992; 9: 120-2.Portis R., Jacobs M.A., Skerman J.H., Skerman E.B. HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) pathophysiology and anesthetic considerations. AANA J. 1997; 65: 37-47.Dotsch J., Hohmann M., Kuhl P.G. Neonatal morbidity and mortality associated with maternal haemolysis, elevated liver enzymes and low platelets syndrome. Eur. J. Pediatr. 1997; 156: 389-91.O‘Hara Padden M. HELLP Syndrome: Recognition and Perinatal Management. Am. Fam. Physician. 1999; 60(3): 829-36; 839.Sullivan C.A., Magann E.F., Perry K.G. Jr, Roberts W.E., Blake P.G., Martin J.N. Jr. The recurrence risk of the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP) in subsequent gestations. Am. J. Obstet. Gynecol. 171: 940-3.Sibai B.M., Taslimi M.M., el-Nazer A., Amon E., Mabie B.C., Ryan G.M. Maternal-perinatal outcome associated with the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe preeclampsia-eclampsia. Am. J. Obstet. Gynecol. 1986; 155: 501-9.Munday D.N., Jones W.R. Pregnancy complicated by the antiphospholipid syndrome. Aust. N. Z. J. Obstet. Gynaecol. 1993; 33: 255-8.Montan S. Medical prevention of preeclampsia. Acta Obstet. Gynecol. Scand. Suppl. 1997; 164: 111-5.Caritis S., Sibai B., Hauth J., Lindheimer M.D., Klebanoff M., Thom E. et al. Low-dose aspirin to prevent preeclampsia in women at high risk. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. N. Engl. J. Med. 1998; 338: 701-5.Lopez-Jaramillo P., Delgado F., Jacome P., Teran E., Ruano C., Rivera J. Calcium supplementation and the risk of preeclampsia in Ecuadorian pregnant teenagers. Obstet .Gynecol. 1997; 90: 162-7.Bucher H., Guyatt G., Cook R.J., Hatala R., Cook D.J., Lang J.D., et al. Effect of calcium supplementation on pregnancy-induced hypertension and preeclampsia: a meta-analysis of randomized controlled trials. JAMA. 1996; 275: 1113-7 [Published erratum in JAMA. 1996; 276: 1388].Levine R.J., Hauth J.C., Curet L.B., Sibai B.M., Catalano P.M., Morris C.D., et al. Trial of calcium to prevent preeclampsia. N. Engl. J. Med. 1997; 337: 69-76.