Application of PRP-therapy in assisted reproductive technology

According to the World Health Organization, infertility affects 17.5% of the adult population worldwide and remains a serious medical and social challenge. Despite significant progress in assisted reproductive technologies, the treatment of infertility associated with endometrial disorder and ovarian dysfunction remains relevant and requires the search for new therapeutic approaches.

This review analyzes current data from Russian and international sources published over the past 5 years on the use of autologous platelet-rich plasma (PRP) as a promising therapeutic modality in assisted reproductive technology programs. The search for published data was conducted in PubMed, eLibrary, and Google Scholar databases. Analysis of the publications demonstrated that PRP therapy is clinically effective in treating thin endometrium, recurrent implantation failure, and premature ovarian insufficiency and may also improve the clinical pregnancy rate. However, the available studies are limited by small sample sizes and nonrandomized designs, precluding definitive conclusions regarding the efficacy and safety of PRP therapy. Additionally, different routes of administration, injected plasma volumes, and platelet concentrations are currently in use. However, their efficacy has not been compared against one another but only against control groups receiving conservative therapy. This technology requires further investigation in randomized clinical trials to develop standardized protocols and evaluate long-term outcomes.