Porphyrins as polyfunctional ligands for binding to DNA. Prospects for application

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The study of the interaction of nucleic acids with ligands is relevant not only from a scientific point of view, but also has high potential practical significance. Complexes of nucleic acids with ligands affect the biochemical functions of the most important carrier of genetic information, which opens up opportunities for treating genetic diseases and controlling the aging of both cells and the organism as a whole. Among the huge variety of potential ligands, porphyrins and related compounds occupy a special place, due to their ability to generate reactive oxygen species under irradiation with light. The photocatalytic properties of porphyrins can be used in the creation of molecular tools for genetic engineering and the treatment of viral and bacterial infections at the genetic level. Modification of porphyrin compounds allows targeting of the ligand to a specific biological target. The review summarizes the literature data describing the processes of complexation of nucleic acids with aromatic ligands, mainly with porphyrins. The influence of the structure of macroheterocyclic compounds on the features of interaction with nucleic acids is analyzed. Promising directions for further research are outlined.

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N. Lebedeva

Institute of Chemistry of Solutions named after G.A. Krestov, Russian Academy of Sciences

Email: yurina_elena77@mail.ru
俄罗斯联邦, ul. Academicheskaya 1, Ivanovo, 153045

E. Yurina

Institute of Chemistry of Solutions named after G.A. Krestov, Russian Academy of Sciences

编辑信件的主要联系方式.
Email: yurina_elena77@mail.ru
俄罗斯联邦, ul. Academicheskaya 1, Ivanovo, 153045

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2. Fig. 1. Visualization of parallel (a) or perpendicular (b) intercalation with respect to DNA base pairs (blue) [12].

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3. Fig. 2. Modification of proflavine to increase the affinity and selectivity of DNA binding [14].

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4. Fig. 3. 3D image of DNA intercalation complexes with bisintercalates: bisdaunomycin and TOTO [12].

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5. Fig. 4. 3D image of intercalation complexes of DNA with nogalamycin. Additional binding of peripheral substituents to fragments of the minor and major grooves is realized [12].

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6. Fig. 5. Structural formulas of tetra- and dicationic porphyrins/metalloporphyrins.

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7. Fig. 6. (a) – Image of a continuous helix observed in the crystal of d(CGATCG) CuTMPyP4; (b) – total electron density of the d(CGATCG)–CuTMPyP4 complex; (c) – model of the d(CGATCG) CuTMPyP4 complex [58].

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8. Fig. 7. Unsymmetrical cationic porphyrins containing residues of heteroaromatic molecules.

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