Biochemical Indicator of Isometric Exercises Effectiveness in Early Rehabilitation of Elderly Patients after Hip Arthroplasty

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

Improving the effectiveness of early rehabilitation of elderly patients after hip arthroplasty remains an urgent task. The aim of the study was to evaluate the effectiveness of isometric exercises in early (2 weeks) rehabilitation of elderly patients after hip replacement using blood parameters. The randomized study included 10 elderly patients in the groups of control (n = 5) and experimental (n = 5), supplemented with isometric exercises, rehabilitation techniques performed daily from 1 to 12 days after total cement hip arthroplasty. The effectiveness of rehabilitation was assessed by the indices of muscle traumatization (myoglobin, creatine phosphokinase, aspartate aminotransferase, lactate dehydrogenase concentration) and systemic inflammation (erythrocyte sedimentation rate, CRP concentrations, and interleukins IL-6, IL-8, and IL-1β) in the blood of patients on the 12th day after surgery. The indices of muscle traumatization, concentration of C-reactive protein and leukocytes in blood, as well as erythrocyte sedimentation rate did not reveal any significant difference between the groups of patients. The difference between the control and experimental groups in terms of restoration of interleukin IL-6, IL-8, and IL-1β concentrations in the blood to the normal range was statistically reliable according to Fisher’s exact criterion (p = 0.042). In general, the obtained results showed that additional isometric exercises provided more effective early rehabilitation of elderly patients after endoprosthesis in comparison with the standard set of exercises, and normalization of the concentration of proinflammatory interleukins, primarily IL-6 and IL-8, can be considered as an objective indicator in assessing the effectiveness of methods of early rehabilitation of elderly patients after hip arthroplasty.

Авторлар туралы

E. Maksimova

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Email: maksimova.elena@inbox.ru
Pushchino, Russia

V. Shevchenko

Hospital of the Pushchino Scientific Center of the Russian Academy of Sciences

Pushchino, Russia

K. Krasnov

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Pushchino, Russia

A. Senotov

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Pushchino, Russia

O. Lobanova

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Pushchino, Russia

V. Akatov

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Email: akatov.vladimir@gmail.com
Pushchino, Russia

Әдебиет тізімі

  1. Епифанов В. А. и Епифанов А. В. Лечебная физическая культура: учебное пособие (ГЭОТАР-Медиа, М., 2020). DOI: 1033029/9704-5576-0-2020-PHY-1-704
  2. Клинические рекомендации «Коксартроз» (утв. Минздравом России) (ЦЕНТРМАГ, М., 2024).
  3. Физическая и реабилитационная медицина: национальное руководство, под ред. Г. Н. Пономаренко (ГЭОТАР-Медиа, М., 2020).
  4. Bullova T. M., Bodrova R. A., and Petrova R. V. Rehabilitation diagnosis based on the International Functioning Classification (ICF) in patients under lower limb joint endoprosthetics. Bul. Rehabilit. Med., 21 (2), 17–26 (2022). doi: 10.38025/2078-1962-2022-21-2-17-26
  5. Климовицкий В. Г., Климовицкий Р. В., Тяжелов А. А. и Гончарова Л. Е. Особенности работы мышц тазового пояса до и после эндопротезирования тазобедренного сустава. Обзор литературы. Травма, 20 (2), 13–19 (2019). doi: 10.22141/1608-1706.2.20.2019.168016
  6. Новикова С. Л. Евразийский патент на изобретение № 010788 B1 (2008).
  7. Зайцев Н. М., Яруллина Т. С., Авдониченко Т. С., Яруллин И. М., Пронских А. А., Касатова А. И., Касатова Д. А. и Рыжик Е. Е. Российский патент на изобретение RU 2725245, Бюл. 19 (2020).
  8. Лапшин В. П., Чукина Е. А., Клюквин И. Ю., Антонов В. В., Ларионов К. С. и Боголюбский Ю. А. Лечебная гимнастика в восстановительном лечении больных похищного и старческого возраста после эндопротезирования тазобедренного сустава. Вопросы курортологии и физиотерапии, 4, 37 (2002).
  9. Mikkeisen L. R., Mechlenburg I., Soballe K., Jorgensen L. B., Mikkeisen S., Bandholm T., and Petersen A. K. Effect of early supervised progressive resistance training compared to unsupervised home-based exercise after fast-track total hip replacement applied to patients with preoperative functional limitations. A single-blinded randomised controlled trial. Osteoarthritis Cartilage, 22 (12), 2051–2058 (2014). doi: 10.1016/j.joca.2014.09.025
  10. Madara K. C., Marmon A., Aljehani M., Hunter-Giordano A., Zeni J. Jr., and Raisis L. Progressive rehabilitation after total hip arthroplasty: a pilot and feasibility study. Int. J. Sports Phys. Ther., 14 (4), 564–581 (2019). doi: 10.26603/jsp020190564
  11. Suetta C., Magnusson S. P., Rosted A., Aagaard P., Jakobsen A. K., Larsen L. H., Duus B., and Kjaer M. Resistance training in the early postoperative phase reduces hospitalization and leads to muscle hypertrophy in elderly hip surgery patients – a controlled, randomized study. J. Am. Geriatr. Soc., 52 (12), 2016–2022 (2004). doi: 10.1111/j.1532-5415.2004.52557.x
  12. Кироненко Т. А. Профукция миокинов и концентрация одноадентных катионов в мышечной ткани мышей при физических нагрузках. Дис. ... канд. биол. наук (ТГУ, Томск, 2021).
  13. Snenkman B. S., Nemirovskaya T. L., and Lomonosova Y. N. No-dependent signaling pathways in unloaded skeletal muscle. Front. Physiol., 6, 298 (2015). doi: 10.3389/fphys.2015.00298
  14. Reza Y. M., Nassour A., Reza A., Kaveh Kh., Ahmed V., and Mohammed N. The effect of isometric training on prevention of density reduction in injured limbs during a period of immobilization. Aust. J. Basic Appl. Sci., 5 (12), 981–985 (2011).
  15. Taufik N. H., Tulnar A. B. M., Moesbar N., and Ganic R. A. The effect of isometric exercise plantar flexor on osteoblast activity measured by bone specific alkaline phosphatase and callus formation in a patient post open reduction internal fixation with non-articular tibia fracture. Open Access Maced. J. Med. Sci., 7 (20), 3409–3415 (2019). doi: 10.3889/oamjms.2019.435
  16. Qi C., Song X., Wang H., Yan Y., and Liu B. The role of exercise-induced myokines in promoting angiogenesis. Front. Physiol., 13, 981577 (2022). doi: 10.3389/fphys.2022.981577
  17. Dyakova E. Y., Kapilevich L. V., Shylko V. G., Popov S. V., and Anfinogenova Y. Physical exercise associated with NO production: signaling pathways and significance in health and disease. Front. Cell Dev. Biol., 3, 19 (2015). doi: 10.3389/fcell.2015.00019
  18. Максимова Е. А., Шевченко В. И. и Акатов В. С. Биофизические основы применения изометрических упражнений в реабилитации пациентов после эндопротезирования. Биофизика, 70 (1), 198–208 (2025). doi: 10.31857/S0006302925010249
  19. Komyu K. J., Pinto D., Cao W., Aaron R. K., Panagiotou O. A., Bhuma M. R., Adam G. P., Balk E. M., and Thoma L. M. Rehabilitation for total hip arthroplasty: A systematic review. Am. J. Phys. Med. Relabili., 102 (1), 11–18 (2023). doi: 10.1097/PHM.00000000000002007
  20. Максимова Е. А., Акатов В. С., Шевченко В. И., Сенотов В. С. и Краснов К. С. Способ ранней реабилитации пациентов после эндопротезирования тазобедренного сустава. Заявка на изобретение № 2024140224 от 28.12.2024. https://fips.ru/registers-doc-view/fips_server?DB=RUPAT&DocNumber=2024140224&Type=File=html.
  21. Синеский А. Д., Плиев Д. Г., Гущаев М. С., Ефимов Н. Н., Стафеев Д. В., Михайлов К. С. и Несинов А. А. Сравнительный анализ биохимических маркеров тканевой травматизации в зависимости от используемого хирургического доступа при ревизионном эндопротезировании тазобедренного сустава. Современные проблемы науки и образования, 4, 146 (2020).
  22. Тихилов Р. М., Андреев Д. В., Гончаров М. Ю., и Швейдер О. В. Сравнительный анализ биохимических показателей альтерации мышечной ткани в зависимости от доступа при тотальном эндопротезировании тазобедренного сустава. Травматология и ортопедия России, 1, 37–43 (2013).
  23. Laurence A. S. Serum myoglobin and creatine kinase following surgery. Br. J. Anaesth., 84 (6), 763–766 (2000). doi: 10.1093/oxfordjournals.bja.a013590
  24. Антонов А. А., Решетникова В. В., Должикова Ю. И., Солод Э. И., Лазарев А. Ф., Антонов А. К., Горенков Р. В., Симонова А. В. и Тапипов И. А. Воспалительные маркеры в раннем послеоперационном периоде у пациентов, перенесших тотальное эндопротезирование тазобедренного сустава при застарелых вертельных переломах бедренной кости. Вестн. HMXII им. Н.Н. Пирогова, 17 (4), 46–50 (2022). doi: 10.25881/20728255_2022_17_4_2_46
  25. Krishna A., Garg S., Gupta S., and Bansal H. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) trends following total hip and knee arthroplasties in an indian population – A prospective study. Malays. Orthop. J., 15 (2), 143–150 (2021). doi: 10.5704/MOJ.2107.021
  26. Bilgen Ö., Atiel T., Durak K., Karanningöllari O., and Bilgen M. C-Reactive protein values and erythrocyte sedimentation rates after total hip and total knee arthroplasty. J. Int. Med. Res., 29 (1), 7–12 (2001). doi: 10.1177/147323000102900102
  27. Kwon Y. S., Jang J. S., Hwang S. M., Tark H., Kim J. H., and Lee J. J. Effects of surgery start time on postoperative cortisol, inflammatory cytokines, and postoperative hospital day in hip surgery. Randomized controlled trial. Medicine (Baltimore), 98 (24), e15820 (2019). doi: 10.1097/MD.0000000000015820
  28. Minetto M. A., Oprandi G., Saba L., Mussino S., Aprato A., Masse A., Angeli A., and Gallinaro P. Serum interleukin-6 response to elective total hip replacement surgery. Int. Orthop., 30 (3), 172–176 (2006). doi: 10.1007/s00264-006-0073-3
  29. Domecky P., Rejman Patkova A., Mala-Ladova K., and Maly J. Inflammatory blood parameters as prognostic factors for implant-associated infection after primary total hip or knee arthroplasty: a systematic review. BMC Musculoskelet. Disord., 24 (1), 383 (2023). doi: 10.1186/s12891-023-06500-z
  30. Huang Z. Y., Huang Q., Wang L. Y., Lei Y. T., Xu H., Shen B., and Pei F. X. Normal trajectory of Interleukin-6 and C-reactive protein in the perioperative period of total knee arthroplasty under an enhanced recovery after surgery scenario. BMC Musculoskelet. Disord., 21 (1), 264 (2020). doi: 10.1186/s12891-020-03283-5
  31. Sereda A. P., Rukina A. N., Trusova Y. V., Dzhavadov A. A., Cherny A. A., Bozhkova S. A., Shubnyakov I. I., and Tikhilov R. M. Dynamics of C-reactive protein level after orthopedic surgeries. J. Orthop., 47, 1–7 (2023). doi: 10.1016/j.jor.2023.11.014

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
Жүктеу

© Russian Academy of Sciences, 2025